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Molecular signaling
Viñals’s lab

DESCRIPTION

Our research is focused on the study of the implication of intracellular signaling cascades driving to pathological situations in cancer and vascular diseases.

The molecular signaling cascades that take place inside the cells are essential to respond to changes in their environment or to alter their homeostasis, for example, at the level of cell proliferation, movement, growth or metabolism. Understanding how these mechanisms of signal transduction work can explain how biological processes are controlled in a normal physiological context, but also, the alterations that take place in many pathologies. Our group investigates this in two pathological contexts: The first is ovarian epithelial cancer, where we study the pathways involved in metastasis and the mechanisms of resistance to therapies. A second context is a rare vascular disease, HHTs, in which, in collaboration with the group led by Toni Riera (Hospital de Bellvitge), we study which signaling pathways are altered in patients with mutations that cause this disease, and how treat them with new drugs.

Group members

Francesc Viñals

Group leaders

Group Leader

Agnès Figueras

Researchers

Núria Gendrau Sanclemente

PhD student

Ferran Medina Jover

PhD student

José Luís Rocamora

PhD student

Tianyu Dai

PhD student

Publications

Generation and Integrated Analysis of Advanced Patient-Derived Orthoxenograft Models (PDOX) for the Rational Assessment of Targeted Therapies in Endometrial Cancer

14 de November de 2022/in Viñals's lab/by miguel

Adv Sci (Weinh). 2022 Nov 14;10(1):e2204211. doi: 10.1002/advs.202204211. Online ahead of print. ABSTRACT Clinical management of endometrial cancer (EC) is handicapped by the limited availability of second line treatments and bona fide molecular biomarkers to predict recurrence. These limitations have hampered the treatment of these patients, whose survival rates have not improved over the last […]

https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg 0 0 miguel https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg miguel2022-11-14 11:00:002022-11-14 11:00:00Generation and Integrated Analysis of Advanced Patient-Derived Orthoxenograft Models (PDOX) for the Rational Assessment of Targeted Therapies in Endometrial Cancer

Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells

24 de August de 2022/in Viñals's lab/by miguel

Cell Death Dis. 2022 Aug 24;13(8):730. doi: 10.1038/s41419-022-05177-x. ABSTRACT On glucose restriction, epithelial cells can undergo entosis, a cell-in-cell cannibalistic process, to allow considerable withstanding to this metabolic stress. Thus, we hypothesized that reduced protein glycosylation might participate in the activation of this cell survival pathway. Glucose deprivation promoted entosis in an MCF7 breast carcinoma […]

https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg 0 0 miguel https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg miguel2022-08-24 10:00:002022-08-24 10:00:00Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells

Rethinking growth factors: the case of BMP9 during vessel maturation

30 de March de 2022/in Viñals's lab/by miguel

Vasc Biol. 2022 Feb 7;4(1):R1-R14. doi: 10.1530/VB-21-0019. eCollection 2022 Feb 1. ABSTRACT Angiogenesis is an essential process for correct development and physiology. This mechanism is tightly regulated by many signals that activate several pathways, which are constantly interacting with each other. There is mounting evidence that BMP9/ALK1 pathway is essential for a correct vessel maturation. […]

https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg 0 0 miguel https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg miguel2022-03-30 10:00:002022-03-30 10:00:00Rethinking growth factors: the case of BMP9 during vessel maturation

Translational medicine in hereditary hemorrhagic telangiectasia

20 de September de 2021/in Viñals's lab/by miguel

Eur J Intern Med. 2022 Jan;95:32-37. doi: 10.1016/j.ejim.2021.09.003. Epub 2021 Sep 16. ABSTRACT Scientific community have gained lots of new insights in the genetic and biochemical background of different conditions, rare diseases included, settling the basis for preclinical models that are helping to identify new biomarkers and therapeutic targets. Translational Medicine (TM) is an interdisciplinary […]

https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg 0 0 miguel https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg miguel2021-09-20 10:00:002021-09-20 10:00:00Translational medicine in hereditary hemorrhagic telangiectasia

Histamine signaling and metabolism identify potential biomarkers and therapies for lymphangioleiomyomatosis

11 de August de 2021/in Viñals's lab/by miguel

EMBO Mol Med. 2021 Sep 7;13(9):e13929. doi: 10.15252/emmm.202113929. Epub 2021 Aug 11. ABSTRACT Inhibition of mTOR is the standard of care for lymphangioleiomyomatosis (LAM). However, this therapy has variable tolerability and some patients show progressive decline of lung function despite treatment. LAM diagnosis and monitoring can also be challenging due to the heterogeneity of symptoms […]

https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg 0 0 miguel https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg miguel2021-08-11 10:00:002021-08-11 10:00:00Histamine signaling and metabolism identify potential biomarkers and therapies for lymphangioleiomyomatosis
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Research Projects

– Ref: PID2020-117815RB-I00 Title: El perfil metabólico como una oportunidad terapéutica en el cáncer epitelial de ovario. implicaciones en metástasis y resistencia a los tratamientos. DGICYT, MINECO. 2021-2024. 217.800 euros. Principal Investigator: Francesc Viñals Canals, IDIBELL.

– Ref: SAF2017-85869-R Title: Mecanismos de señalización y control metabólico implicados en la diseminación y quimioresistencia en cáncer epitelial de ovario. DGICYT, MINECO. 2018-2020. 181.500 euros. Principal Investigator: Francesc Viñals Canals, IDIBELL.

Collaborations

Peter B. Vermeulen, University of Antwerp and GZA Hospitals, Belgium
Artur Mezheyeuski, VHIO, Barcelona
Pnina Brodt, Mc Gill University, Montreal, Canada
and Liver Metastases Research Network members

Viñals's lab
Program Against Cancer Therapeutic Resistance

CONTACT US

Campus IDIBELL
(L’Hospitalet del Llobregat)
Hospital Duran i Reynals, Gran Via 199,
L’Hospitalet del Llobregat,
Barcelona 08908
Tel. +34 93 260 7952

Campus IGTP-IJC
(Badalona)
Campus Can Ruti – IGTP – Building Muntanya,
Rd. Can Ruti, Camí de les escoles s/n,
Badalona, Barcelona 08916
Tel. +34 93 554 3069

Campus IDIBGI
(Girona)
Parc Hospitalari Martí i Julià de Salt, Dr. Castany s/n,
Salt, Girona 17190
Tel. +34 872 987 087

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