Cancer cell plasticity defines response to immunotherapy in cutaneous squamous cell carcinoma
Nat Commun. 2024 Jun 24;15(1):5352. doi: 10.1038/s41467-024-49718-8. ABSTRACT Immune checkpoint blockade (ICB) approaches have changed the therapeutic landscape for many tumor types. However, half of cutaneous squamous cell carcinoma (cSCC) patients remain unresponsive or develop resistance. Here, we show that, during cSCC progression in male mice, cancer cells acquire epithelial/mesenchymal plasticity and change their immune […]



