Program Against Cancer Therapeutic Resistance

Our commitment is to fight cancer resistance

WELCOME

Mission

ProCURE is a research program of the Catalan Institute of Oncology (ICO) and its associated CERCA Institutes, the Bellvitge Biomedical Research Institute (IDIBELL), The Germans Trias i Pujol Research Institute (IGTP-IJC) and the Girona Biomedical Research Institute (IDIBGI), aimed at addressing a major clinical problem in oncology; the existence or emergence of therapeutic resistance. As public service, our commitment is to reduce the impact of cancer on health care.

Resistance to therapy is the most common cause of failure of cancer cure and affects, to a different extent, all types of tumors and therapies. This fundamental clinical problem impairs the cure of up to 70-80% of the cases of relatively frequent cancer types appearing in the general population. As part of the public health system, the ICO and ProCURE commitment is to reduce the health impact of cancer and, thus, to connect professional and technological efforts to enhance our understanding of “why” there is no therapeutic benefit in some patients. In this scenario, ProCURE aims to identify and translate useful and precise biomarkers, and beneficial therapeutic strategies against cancer resistance.

To comprehensively and successfully address the problem of resistance, multidisciplinary teams are needed. Thus, ProCURE is constituted by eleven research groups within a comprehensive cancer center (ICO) that represents a reference in the country. ProCURE studies all major types of cancer and their therapies, as well as less common neoplasms that, due to their clinical impact, urgently need beneficial therapeutic options. Research projects include targeted and chemotherapy resistances, and novel approaches based on immunotherapy, perturbations of metabolism and the tumor microenvironment.

OUR VALUES AND STRATEGIC GOALS

We research for patients.

Our research is focused on patients, from diagnosis to treatment and/or progression.

We are committed to transfer knowledge.

We transfer our novel results to improve clinical care and quality of life, and support wealth creation for the benefit of society as a whole.

We work in multi-disciplinary teams.

Our cancer research is carried out in complementary multi-disciplinary teams, addressing various types of cancer and employing a variety of experimental approaches.

We transfer our results to generate value and promote return to society for the benefit of patients

Research-group

Our research groups address the problem of therapeutic resistance in cancer from various perspectives and nuances, in solid and hematological tumors, studying the molecular mechanisms that lead to resistance, using complex experimental models as well as therapeutic interventions to overcome it.

Publications

Autologous stem cell transplantation in POEMS syndrome: Multicenter real-world treatment patterns and outcomes

POEMS syndrome is a rare multisystem plasma cell disorder for which evidence guiding management is largely derived from single-center retrospective…

MRD dynamics predicts progression and reveals a vulnerable state for immunotherapy interception in multiple myeloma

The clinical significance of one or two measurable residual disease (MRD) assessments is established in multiple myeloma (MM). However, how…

Eltrombopag Added to Standard Immunosuppressive Treatment as Front-Line Therapy for Severe Aplastic Anemia: Long-Term Outcomes of the Phase-3 Randomized Superiority EBMT-SAAWP RACE Study

The RACE study (NCT02009747) compared horse antithymocyte globulin (hATG) plus cyclosporine A (CsA) ± eltrombopag as initial immunosuppressive treatment (IST)…

Erratum for Laporte-Amargos et al., "Population pharmacokinetics and optimized dosing of piperacillin-tazobactam in hematological patients with febrile neutropenia"

PMID:42455077 | DOI:10.1128/aac.00740-26

Aneuploidy selects for the acquisition of driver genes in breast cancer

Chromosome instability is highly prevalent in cancer and drives large-scale chromosomal imbalances, known as aneuploidies1-4. How aneuploidy contributes to tumorigenesis…

Aneuploidy selects for the acquisition of driver genes in breast cancer

BACKGROUND: Tetraspanin CD37, highly expressed in mature B-cells, represents an opportunity for therapeutic targeting in B-cell malignancies. GEN3009 (DuoHexaBody-CD37), a…

Autologous and allogeneic haematopoietic cell transplantation in adult patients with Hodgkin lymphoma: recommendations from the EBMT Practice Harmonisation and Guidelines Committee and Lymphoma Working Party

The European Group for Blood and Bone Marrow transplantation Practice Harmonization and Guidelines Committee together with the Lymphoma Working Party…

Exploring glucocorticoid receptor signalling in lymphangioleiomyomatosis

BACKGROUND: Lymphangioleiomyomatosis (LAM) is a rare, low-grade neoplasm that causes progressive cystic lung destruction and is often associated with renal…

Silibinin is a natural molecular glue that inhibits PD-L1 glycomaturation

BACKGROUND: The adaptive upregulation of the immune-checkpoint PD-L1 in response to interferon-γ (IFNγ) protects solid tumors from cytotoxic lymphocytes and…

Jobs

You will join a community of outstanding researchers and excellent professionals dedicated to fight cancer therapeutic resistance from a translational perspective, close to the patient to generate new knowledge that benefits them. We adhere to equal opportunities regardless of your gender, nationality, race or belief.

Join us, we are interested in your dedication, commitment and excellence.

Our goal is to make cancer therapeutic resistance an issue of the past, for a hopeful horizon

Contact

Contact ProCURE – Campus IDIBELL
Hospital Duran i Reynals, Gran Via 199,
L’Hospitalet del Llobregat, Barcelona 08908
Tel: +34 93 260 7952

Contact ProCURE – Campus IGTP-IJC
Campus Can Ruti – IGTP – Building Muntanya,
Rd. Can Ruti, Camí de les escoles s/n,
Badalona, Barcelona 08916
Tel: +34 93 554 3069

Contact ProCURE – Campus IDIBGI
Parc Hospitalari Martí i Julià de Salt,
Dr. Castany s/n, Salt, Girona 17190
Tel: +34 872 987 087

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