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Molecular signaling
Viñals’s lab

DESCRIPTION

Our research is focused on the study of the implication of intracellular signaling cascades driving to pathological situations in cancer and vascular diseases.

The molecular signaling cascades that take place inside the cells are essential to respond to changes in their environment or to alter their homeostasis, for example, at the level of cell proliferation, movement, growth or metabolism. Understanding how these mechanisms of signal transduction work can explain how biological processes are controlled in a normal physiological context, but also, the alterations that take place in many pathologies. Our group investigates this in two pathological contexts: The first is ovarian epithelial cancer, where we study the pathways involved in metastasis and the mechanisms of resistance to therapies. A second context is a rare vascular disease, HHTs, in which, in collaboration with the group led by Toni Riera (Hospital de Bellvitge), we study which signaling pathways are altered in patients with mutations that cause this disease, and how treat them with new drugs.

Group members

Francesc Viñals

Group leaders

Group Leader

Agnès Figueras

Researchers

Núria Gendrau Sanclemente

PhD student

Ferran Medina Jover

PhD student

José Luís Rocamora

PhD student

Tianyu Dai

PhD student

Publications

Evolution of angiogenic and inflammatory biomarkers in patients with hereditary hemorrhagic telangiectasia during treatment with bevacizumab: study protocol

7 de October de 2025/in Viñals's lab/by

Rev Clin Esp (Barc). 2025 Oct 5:502370. doi: 10.1016/j.rceng.2025.502370. Online ahead of print. ABSTRACT BACKGROUND: Hereditary haemorrhagic telangiectasia (HHT) is a rare disease characterized by mucocutaneous telangiectasia and visceral vascular malformations. Treatment with bevacizumab is recommended in patients with liver involvement and high output heart failure (HOHF) or those with severe gastrointestinal (GI) involvement. However, […]

https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg 0 0 https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg 2025-10-07 10:00:002025-10-07 10:00:00Evolution of angiogenic and inflammatory biomarkers in patients with hereditary hemorrhagic telangiectasia during treatment with bevacizumab: study protocol

Anomalies on anterior and posterior complex views in fetuses with partial agenesis of corpus callosum

11 de July de 2025/in Viñals's lab/by

Ultrasound Obstet Gynecol. 2025 Jul 11. doi: 10.1002/uog.29292. Online ahead of print. ABSTRACT OBJECTIVE: The aim of the present study was to describe abnormal anatomical features of the anterior (AC) and posterior (PC) complexes identified during basic ultrasound assessment of the fetal brain in cases diagnosed with partial agenesis of the corpus callosum (pACC). METHODS: […]

https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg 0 0 https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg 2025-07-11 10:00:002025-07-11 10:00:00Anomalies on anterior and posterior complex views in fetuses with partial agenesis of corpus callosum

Transvaginal ultrasound assessment of corpus callosal length in the fetus: multicenter cross-sectional study

5 de May de 2025/in Viñals's lab/by

Ultrasound Obstet Gynecol. 2025 May 5. doi: 10.1002/uog.29227. Online ahead of print. ABSTRACT OBJECTIVE: To produce reference ranges and Z-scores for corpus callosal (CC) length in the fetus, based on transvaginal three-dimensional (3D) ultrasound imaging. METHODS: This was a cross-sectional multicenter retrospective study based on 3D volume dataset acquisitions of the fetal CC between the […]

https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg 0 0 https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg 2025-05-05 10:00:002025-05-05 10:00:00Transvaginal ultrasound assessment of corpus callosal length in the fetus: multicenter cross-sectional study

Harnessing transcriptional regulation of alternative end-joining to predict cancer treatment

10 de March de 2025/in Viñals's lab/by

NAR Cancer. 2025 Mar 7;7(1):zcaf007. doi: 10.1093/narcan/zcaf007. eCollection 2025 Mar. ABSTRACT Alternative end-joining (alt-EJ) is an error-prone DNA repair pathway that cancer cells deficient in homologous recombination rely on, making them vulnerable to synthetic lethality via inhibition of poly(ADP-ribose) polymerase (PARP). Targeting alt-EJ effector DNA polymerase theta (POLθ), which synergizes with PARP inhibitors and can […]

https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg 0 0 https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg 2025-03-10 10:00:002025-03-10 10:00:00Harnessing transcriptional regulation of alternative end-joining to predict cancer treatment

Posterior complex: clue for suspicion of partial agenesis of corpus callosum at fetal brain screening

30 de October de 2024/in Viñals's lab/by

Ultrasound Obstet Gynecol. 2024 Oct 30. doi: 10.1002/uog.29136. Online ahead of print. NO ABSTRACT PMID:39476190 | DOI:10.1002/uog.29136

https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg 0 0 https://procure-oncology.com/wp-content/uploads/2023/10/Procure-icoRecurso-1@2x-100.jpg 2024-10-30 10:00:002024-10-30 10:00:00Posterior complex: clue for suspicion of partial agenesis of corpus callosum at fetal brain screening
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Research Projects

– Ref: PID2020-117815RB-I00 Title: El perfil metabólico como una oportunidad terapéutica en el cáncer epitelial de ovario. implicaciones en metástasis y resistencia a los tratamientos. DGICYT, MINECO. 2021-2024. 217.800 euros. Principal Investigator: Francesc Viñals Canals, IDIBELL.

– Ref: SAF2017-85869-R Title: Mecanismos de señalización y control metabólico implicados en la diseminación y quimioresistencia en cáncer epitelial de ovario. DGICYT, MINECO. 2018-2020. 181.500 euros. Principal Investigator: Francesc Viñals Canals, IDIBELL.

Collaborations

Peter B. Vermeulen, University of Antwerp and GZA Hospitals, Belgium
Artur Mezheyeuski, VHIO, Barcelona
Pnina Brodt, Mc Gill University, Montreal, Canada
and Liver Metastases Research Network members

Viñals's lab
Program Against Cancer Therapeutic Resistance

CONTACT US

Campus IDIBELL
(L’Hospitalet del Llobregat)
Hospital Duran i Reynals, Gran Via 199,
L’Hospitalet del Llobregat,
Barcelona 08908
Tel. +34 93 260 7952

Campus IGTP-IJC
(Badalona)
Campus Can Ruti – IGTP – Building Muntanya,
Rd. Can Ruti, Camí de les escoles s/n,
Badalona, Barcelona 08916
Tel. +34 93 554 3069

Campus IDIBGI
(Girona)
Parc Hospitalari Martí i Julià de Salt, Dr. Castany s/n,
Salt, Girona 17190
Tel. +34 872 987 087

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