p70 S6 kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation
J Biol Chem. 1999 Sep 17;274(38):26776-82. doi: 10.1074/jbc.274.38.26776. ABSTRACT In this work, we analyzed the role of the PI3K-p70 S6 kinase (S6K) signaling cascade in the stimulation of endothelial cell proliferation. We found that inhibitors of the p42/p44 MAPK pathway (PD98059) and the PI3K-p70 S6K pathway (wortmannin, Ly294002, and rapamycin) all block thymidine incorporation stimulated […]



