Susceptibility, tumor progression and resistance
Pujana’s Lab

DESCRIPTION

Targeting cancer complexity at origin and progression

Our research is focused on better understanding breast cancer initiation and, from acquired knowledge, to assess targeted prevention strategies. In parallel, we study pan-cancer vulnerabilities and the connection to a rare, lung metastatic disease, lymphangioleiomyomatosis (LAM).

Group members

Miquel Angel Pujana

Group leaders

Principal investigator

Francesca Mateo

Researchers

Research assistant

Roderic Espín

Young investigators

PhD student

Lara Ruiz

Young investigators

PhD student

Arzoo Shabbir

Young investigators

PhD student

Luís Alfaro

Young investigators

PhD student

Publications

Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis

1 de July de 2021/in Pujana's Lab/by miguel

J Clin Invest. 2021 Jul 1;131(13):e152424. doi: 10.1172/JCI152424. NO ABSTRACT PMID:34196309 | PMC:PMC8245164 | DOI:10.1172/JCI152424

Mammary epithelial cells have lineage-rooted metabolic identities

25 de May de 2021/in Pujana's Lab/by miguel

Nat Metab. 2021 May;3(5):665-681. doi: 10.1038/s42255-021-00388-6. Epub 2021 May 20. ABSTRACT Cancer metabolism adapts the metabolic network of its tissue of origin. However, breast cancer is not a disease of a single origin. Multiple epithelial populations serve as the culprit cell of origin for specific breast cancer subtypes, yet our knowledge of the metabolic network […]

Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

15 de May de 2021/in Pujana's Lab/by miguel

Nat Commun. 2021 May 14;12(1):2986. doi: 10.1038/s41467-021-23162-4. ABSTRACT A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-23162-4. PMID:33990587 | PMC:PMC8121813 | DOI:10.1038/s41467-021-23162-4

Long-term results of sirolimus treatment in lymphangioleiomyomatosis: a single referral centre experience

14 de May de 2021/in Pujana's Lab/by miguel

Sci Rep. 2021 May 13;11(1):10171. doi: 10.1038/s41598-021-89562-0. ABSTRACT There are few published data on long-term treatment with sirolimus in lymphangioleiomyomatosis (LAM). The objective of this study was to describe the long-term effect of sirolimus in a series of LAM patients followed up in a referral centre, focusing on pulmonary function. We retrospectively reviewed a series […]

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

18 de February de 2021/in Pujana's Lab/by miguel

Nat Commun. 2021 Feb 17;12(1):1078. doi: 10.1038/s41467-020-20496-3. ABSTRACT Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but […]

Research Projects

The group works and collaborates to decipher the systems mechanisms of cancer development and progression, with the aim of developing more precise preventive and therapeutic approaches. The group combines in silico and wet-lab studies for the purpose of identifying cancer principles and vulnerabilities.

Collaborations

CIMBA – Consortium of Investigators of Modifiers of BRCA1/2

https://cimba.ccge.medschl.cam.ac.uk/

Lobular Breast Cancer

https://lobsterpot.eu/

BRCA1 breast cancer

Khokha Lab

https://medbio.utoronto.ca/faculty/khokha

Hakem Lab

https://medbio.utoronto.ca/faculty/hakem

Maxwell Lab

https://www.bcchr.ca/cmaxwell

Serra Lab

https://vhio.net/biosketch-violeta-serra/

Cancer biology

Schramek Lab

https://schramek.lunenfeld.ca/

Li Lab

https://lilab.smhs.gwu.edu/

Barcellos-Hoff Lab

https://barcelloshofflab.ucsf.edu/principal-investigator

Cancer genetics

De Cid Lab – GCAT

http://www.gcatbiobank.org/

LAM research

Johnson Lab – LAM UK

https://www.nottingham.ac.uk/medicine/people/simon.johnson

Elżbieta Radzikowska

National Tuberculosis and Lung Diseases Research Institute, Poland

Kwiatkowski Lab

https://www.kwiatkowskilab.org/

AELAM

https://www.aelam.org/

VHIR

https://vhir.vallhebron.com/en/research/pneumology

Molina Lab

https://idibell.cat/en/research/translational-medicine-area/cardiovascular-respiratory-and-systemic-diseases-and-cellular-aging-program/pneumology/

Susceptibility, tumor progression and resistancePujana’s Lab

DESCRIPTION

Miquel Angel Pujana

Group leaders

Francesca Mateo

Researchers

Roderic Espín

Young investigators

Lara Ruiz

Young investigators

Arzoo Shabbir

Young investigators

Luís Alfaro

Young investigators

CONTACT US

Susceptibility, tumor progression and resistance
Pujana’s Lab