Targeting cancer complexity at origin and progression
Our research is focused on better understanding breast cancer initiation and, from acquired knowledge, to assess targeted prevention strategies. In parallel, we study pan-cancer vulnerabilities and the connection to a rare, lung metastatic disease, lymphangioleiomyomatosis (LAM).
Group members
Principal investigator
Research assistant
PhD student
PhD student
PhD student
PhD student
Publications
Hum Mutat. 2021 Nov;42(11):1488-1502. doi: 10.1002/humu.24276. Epub 2021 Aug 31. ABSTRACT Germline pathogenic variants in BRCA1 confer a high risk of developing breast and ovarian cancer. The BRCA1 exon 11 (formally exon 10) is one of the largest exons and codes for the nuclear localization signals of the corresponding gene product. This exon can be […]
J Natl Cancer Inst. 2022 Jan 11;114(1):109-122. doi: 10.1093/jnci/djab147. ABSTRACT BACKGROUND: Recent population-based female breast cancer and prostate cancer polygenic risk scores (PRS) have been developed. We assessed the associations of these PRS with breast and prostate cancer risks for male BRCA1 and BRCA2 pathogenic variant carriers. METHODS: 483 BRCA1 and 1318 BRCA2 European ancestry […]
Mol Cancer Res. 2021 Nov;19(11):1840-1853. doi: 10.1158/1541-7786.MCR-21-0220. Epub 2021 Jul 26. ABSTRACT Lymphangioleiomyomatosis (LAM) is a rare, low-grade metastasizing disease characterized by cystic lung destruction. LAM can exhibit extensive heterogeneity at the molecular, cellular, and tissue levels. However, the molecular similarities and differences among LAM cells and tissue, and their connection to cancer features are […]
J Clin Invest. 2021 Jul 1;131(13):e152424. doi: 10.1172/JCI152424. NO ABSTRACT PMID:34196309 | PMC:PMC8245164 | DOI:10.1172/JCI152424
Nat Metab. 2021 May;3(5):665-681. doi: 10.1038/s42255-021-00388-6. Epub 2021 May 20. ABSTRACT Cancer metabolism adapts the metabolic network of its tissue of origin. However, breast cancer is not a disease of a single origin. Multiple epithelial populations serve as the culprit cell of origin for specific breast cancer subtypes, yet our knowledge of the metabolic network […]
Research Projects
The group works and collaborates to decipher the systems mechanisms of cancer development and progression, with the aim of developing more precise preventive and therapeutic approaches. The group combines in silico and wet-lab studies for the purpose of identifying cancer principles and vulnerabilities.
Collaborations
CIMBA – Consortium of Investigators of Modifiers of BRCA1/2
https://cimba.ccge.medschl.cam.ac.uk/
Lobular Breast Cancer
https://lobsterpot.eu/
BRCA1 breast cancer
Khokha Lab
https://medbio.utoronto.ca/faculty/khokha
Hakem Lab
https://medbio.utoronto.ca/faculty/hakem
Maxwell Lab
https://www.bcchr.ca/cmaxwell
Serra Lab
https://vhio.net/biosketch-violeta-serra/
Cancer biology
Schramek Lab
https://schramek.lunenfeld.ca/
Li Lab
https://lilab.smhs.gwu.edu/
Barcellos-Hoff Lab
https://barcelloshofflab.ucsf.edu/principal-investigator
Cancer genetics
De Cid Lab – GCAT
http://www.gcatbiobank.org/
LAM research
Johnson Lab – LAM UK
https://www.nottingham.ac.uk/medicine/people/simon.johnson
Elżbieta Radzikowska
National Tuberculosis and Lung Diseases Research Institute, Poland
Kwiatkowski Lab
https://www.kwiatkowskilab.org/
AELAM
https://www.aelam.org/
VHIR
https://vhir.vallhebron.com/en/research/pneumology
Molina Lab
https://idibell.cat/en/research/translational-medicine-area/cardiovascular-respiratory-and-systemic-diseases-and-cellular-aging-program/pneumology/
Campus IDIBELL
(L’Hospitalet del Llobregat)
Hospital Duran i Reynals, Gran Via 199,
L’Hospitalet del Llobregat,
Barcelona 08908
Tel. +34 93 260 7952
Campus IGTP-IJC
(Badalona)
Campus Can Ruti – IGTP – Building Muntanya,
Rd. Can Ruti, Camí de les escoles s/n,
Badalona, Barcelona 08916
Tel. +34 93 554 3069
Campus IDIBGI
(Girona)
Parc Hospitalari Martí i Julià de Salt, Dr. Castany s/n,
Salt, Girona 17190
Tel. +34 872 987 087
Menendez’s Lab