Targeting cancer complexity at origin and progression
Our research is focused on better understanding breast cancer initiation and, from acquired knowledge, to assess targeted prevention strategies. In parallel, we study pan-cancer vulnerabilities and the connection to a rare, lung metastatic disease, lymphangioleiomyomatosis (LAM).
Group members
Principal investigator
Research assistant
PhD student
PhD student
PhD student
PhD student
Publications
Oncogene. 2020 Jul;39(30):5252-5266. doi: 10.1038/s41388-020-1361-x. Epub 2020 Jun 19. ABSTRACT In response to genotoxic stress, multiple kinase signaling cascades are activated, many of them directed towards the tumor suppressor p53, which coordinates the DNA damage response (DDR). Defects in DDR pathways lead to an accumulation of mutations that can promote tumorigenesis. Emerging evidence implicates multiple […]
EMBO Mol Med. 2020 Jun 8;12(6):e11217. doi: 10.15252/emmm.201911217. Epub 2020 May 13. ABSTRACT Mitochondrial metabolism and the generation of reactive oxygen species (ROS) contribute to the acquisition of DNA mutations and genomic instability in cancer. How genomic instability influences the metabolic capacity of cancer cells is nevertheless poorly understood. Here, we show that homologous recombination-defective […]
J Clin Med. 2020 Jan 27;9(2):353. doi: 10.3390/jcm9020353. ABSTRACT Traditionally, studies to address the characterization of mechanisms promoting tumor aggressiveness and progression have been focused only on primary tumor analyses, which could provide relevant information but have limitations to really characterize the more aggressive tumor population. To overcome these limitations, circulating tumor cells (CTCs) represent […]
Nat Genet. 2020 Jan;52(1):56-73. doi: 10.1038/s41588-019-0537-1. Epub 2020 Jan 7. ABSTRACT Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic feature annotations. We defined 205 independent risk-associated signals with the […]
Cancer Res. 2020 Feb 1;80(3):624-638. doi: 10.1158/0008-5472.CAN-19-1840. Epub 2019 Nov 13. ABSTRACT Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international […]
Research Projects
The group works and collaborates to decipher the systems mechanisms of cancer development and progression, with the aim of developing more precise preventive and therapeutic approaches. The group combines in silico and wet-lab studies for the purpose of identifying cancer principles and vulnerabilities.
Collaborations
CIMBA – Consortium of Investigators of Modifiers of BRCA1/2
https://cimba.ccge.medschl.cam.ac.uk/
Lobular Breast Cancer
https://lobsterpot.eu/
BRCA1 breast cancer
Khokha Lab
https://medbio.utoronto.ca/faculty/khokha
Hakem Lab
https://medbio.utoronto.ca/faculty/hakem
Maxwell Lab
https://www.bcchr.ca/cmaxwell
Serra Lab
https://vhio.net/biosketch-violeta-serra/
Cancer biology
Schramek Lab
https://schramek.lunenfeld.ca/
Li Lab
https://lilab.smhs.gwu.edu/
Barcellos-Hoff Lab
https://barcelloshofflab.ucsf.edu/principal-investigator
Cancer genetics
De Cid Lab – GCAT
http://www.gcatbiobank.org/
LAM research
Johnson Lab – LAM UK
https://www.nottingham.ac.uk/medicine/people/simon.johnson
Elżbieta Radzikowska
National Tuberculosis and Lung Diseases Research Institute, Poland
Kwiatkowski Lab
https://www.kwiatkowskilab.org/
AELAM
https://www.aelam.org/
VHIR
https://vhir.vallhebron.com/en/research/pneumology
Molina Lab
https://idibell.cat/en/research/translational-medicine-area/cardiovascular-respiratory-and-systemic-diseases-and-cellular-aging-program/pneumology/
Campus IDIBELL
(L’Hospitalet del Llobregat)
Hospital Duran i Reynals, Gran Via 199,
L’Hospitalet del Llobregat,
Barcelona 08908
Tel. +34 93 260 7952
Campus IGTP-IJC
(Badalona)
Campus Can Ruti – IGTP – Building Muntanya,
Rd. Can Ruti, Camí de les escoles s/n,
Badalona, Barcelona 08916
Tel. +34 93 554 3069
Campus IDIBGI
(Girona)
Parc Hospitalari Martí i Julià de Salt, Dr. Castany s/n,
Salt, Girona 17190
Tel. +34 872 987 087
Menendez’s Lab