Targeting cancer complexity at origin and progression
Our research is focused on better understanding breast cancer initiation and, from acquired knowledge, to assess targeted prevention strategies. In parallel, we study pan-cancer vulnerabilities and the connection to a rare, lung metastatic disease, lymphangioleiomyomatosis (LAM).
Group members
Principal investigator
Research assistant
PhD student
PhD student
PhD student
PhD student
Publications
Cancer Epidemiol. 2019 Aug;61:154-156. doi: 10.1016/j.canep.2019.06.004. Epub 2019 Jun 28. ABSTRACT Lymphangioleiomyomatosis (LAM) is a rare metastasizing pulmonary disease that shares some clinical, cellular, and molecular similarities with metastatic breast cancer to lung. LAM cells have been identified circulating in various body fluids of patients and, intriguingly, diverse evidence indicates that these cells may originate […]
Cancer Res. 2019 Aug 15;79(16):4258-4270. doi: 10.1158/0008-5472.CAN-18-3835. Epub 2019 Jun 18. ABSTRACT Taxanes are the mainstay of treatment in triple-negative breast cancer (TNBC), with de novo and acquired resistance limiting patient’s survival. To investigate the genetic basis of docetaxel resistance in TNBC, exome sequencing was performed on matched TNBC patient-derived xenografts (PDX) sensitive to docetaxel […]
Eur Respir J. 2019 Jun 27;53(6):1900329. doi: 10.1183/13993003.00329-2019. Print 2019 Jun. ABSTRACT INTRODUCTION: Lymphangioleiomyomatosis (LAM) occurs either associated with tuberous sclerosis complex (TSC) or as sporadic disease (S-LAM). Risk factors for development of S-LAM are unknown. We hypothesised that DNA sequence variants outside of TSC2/TSC1 might be associated with susceptibility for S-LAM and performed a […]
NPJ Syst Biol Appl. 2019 Mar 1;5:7. doi: 10.1038/s41540-019-0087-2. eCollection 2019. ABSTRACT In spite of the increasing availability of genomic and transcriptomic data, there is still a gap between the detection of perturbations in gene expression and the understanding of their contribution to the molecular mechanisms that ultimately account for the phenotype studied. Alterations in […]
Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4326-4335. doi: 10.1073/pnas.1819473116. Epub 2019 Feb 15. ABSTRACT The combination of immune checkpoint blockade with chemotherapy is currently under investigation as a promising strategy for the treatment of triple negative breast cancer (TNBC). Tumor-associated macrophages (TAMs) are the most prominent component of the breast cancer microenvironment […]
Research Projects
The group works and collaborates to decipher the systems mechanisms of cancer development and progression, with the aim of developing more precise preventive and therapeutic approaches. The group combines in silico and wet-lab studies for the purpose of identifying cancer principles and vulnerabilities.
Collaborations
CIMBA – Consortium of Investigators of Modifiers of BRCA1/2
https://cimba.ccge.medschl.cam.ac.uk/
Lobular Breast Cancer
https://lobsterpot.eu/
BRCA1 breast cancer
Khokha Lab
https://medbio.utoronto.ca/faculty/khokha
Hakem Lab
https://medbio.utoronto.ca/faculty/hakem
Maxwell Lab
https://www.bcchr.ca/cmaxwell
Serra Lab
https://vhio.net/biosketch-violeta-serra/
Cancer biology
Schramek Lab
https://schramek.lunenfeld.ca/
Li Lab
https://lilab.smhs.gwu.edu/
Barcellos-Hoff Lab
https://barcelloshofflab.ucsf.edu/principal-investigator
Cancer genetics
De Cid Lab – GCAT
http://www.gcatbiobank.org/
LAM research
Johnson Lab – LAM UK
https://www.nottingham.ac.uk/medicine/people/simon.johnson
Elżbieta Radzikowska
National Tuberculosis and Lung Diseases Research Institute, Poland
Kwiatkowski Lab
https://www.kwiatkowskilab.org/
AELAM
https://www.aelam.org/
VHIR
https://vhir.vallhebron.com/en/research/pneumology
Molina Lab
https://idibell.cat/en/research/translational-medicine-area/cardiovascular-respiratory-and-systemic-diseases-and-cellular-aging-program/pneumology/
Campus IDIBELL
(L’Hospitalet del Llobregat)
Hospital Duran i Reynals, Gran Via 199,
L’Hospitalet del Llobregat,
Barcelona 08908
Tel. +34 93 260 7952
Campus IGTP-IJC
(Badalona)
Campus Can Ruti – IGTP – Building Muntanya,
Rd. Can Ruti, Camí de les escoles s/n,
Badalona, Barcelona 08916
Tel. +34 93 554 3069
Campus IDIBGI
(Girona)
Parc Hospitalari Martí i Julià de Salt, Dr. Castany s/n,
Salt, Girona 17190
Tel. +34 872 987 087
Menendez’s Lab