Unlocking the metabolic secrets of cancer: Our “Metabolism and Cancer” team studies how cellular metabolism drives cancer growth, drug resistance, and metastasis. We use cutting-edge laboratory experiments, computational tools and clinical trials to validate our discoveries in cancer patients.
MAIN RESEARCH LINES
Metabolic inhibitors for cancer therapy
Mitochondria, senescence, and cancer
Metabolo-immunotherapy
Group members
IP
Established researcher (Miguel Servet)
Postdoctoral researcher (INVESTIGO)
Predoctoral researcher
Predoctoral researcher
Predoctoral researcher
Established researcher (Unit of Clinical Research, ICO-Girona)
Established researcher (Hospital Trueta)
Publications
Aging Cell. 2018 Aug;17(4):e12772. doi: 10.1111/acel.12772. Epub 2018 May 8. ABSTRACT Metformin, the first drug chosen to be tested in a clinical trial aimed to target the biology of aging per se, has been clinically exploited for decades in the absence of a complete understanding of its therapeutic targets or chemical determinants. We here outline […]
Food Chem Toxicol. 2018 Jun;116(Pt B):161-172. doi: 10.1016/j.fct.2018.04.028. Epub 2018 Apr 14. ABSTRACT We herein combined experimental and computational efforts to delineate the mechanism of action through which the flavonolignan silibinin targets STAT3. Silibinin reduced IL-6 inducible, constitutive, and acquired feedback activation of STAT3 at tyrosine 705 (Y705). Silibinin attenuated the inducible phospho-activation of Y705 […]
J Vasc Surg. 2018 Oct;68(4):1135-1142.e6. doi: 10.1016/j.jvs.2017.12.071. Epub 2018 Mar 31. ABSTRACT BACKGROUND: The prevalence of lower extremity artery disease (LEAD) is high (20%-25%) in the population older than 65 years, but patients are seldom identified until the disease is advanced. Circulating markers of disease activity might provide patients with a key opportunity for timely […]
PLoS Comput Biol. 2018 Mar 15;14(3):e1006052. doi: 10.1371/journal.pcbi.1006052. eCollection 2018 Mar. ABSTRACT Understanding the control of epigenetic regulation is key to explain and modify the aging process. Because histone-modifying enzymes are sensitive to shifts in availability of cofactors (e.g. metabolites), cellular epigenetic states may be tied to changing conditions associated with cofactor variability. The aim […]
Carcinogenesis. 2018 Apr 5;39(4):601-613. doi: 10.1093/carcin/bgy023. ABSTRACT Targeting tumor-initiating, drug-resistant populations of cancer stem cells (CSC) with phytochemicals is a novel paradigm for cancer prevention and treatment. We herein employed a phenotypic drug discovery approach coupled to mechanism-of-action profiling and target deconvolution to identify phenolic components of extra virgin olive oil (EVOO) capable of suppressing […]
Collaborations
Ruth Lupu | Mayo Clinic, Rochester, USA
Pilar Blancafort | Harry Perkins Institute of Medical Research, Perth, Australia
Francesca Cutruzzolà | Sapienza University, Rome, Italy
Tomás Alarcón | ICREA-Centre de Recerca Matemàtica (CRM), Reus, Spain
Sílvia Osuna | ICREA-Institut de Química Computacional i Catàlisi (IQCC), Girona, Spain
Josep Sardanyés | Centre de Recerca Matemàtica (CRM), Barcelona, Spain
José Antonio Encinar | Universidad Miguel Hernández, Elche, Spain
Vicente Micol | Universidad Miguel Hernández, Elche, Spain
Antonio Segura-Carretero | Universidad de Granada, Granada, Spain
Jorge Joven | Institut d’Investigació Sanitària Pere Virgili (IISPV), Reus, Spain
Carlos Peña Garay | Laboratorio Subterráneo de Canfranc (LSC), Spain
Campus IDIBELL
(L’Hospitalet del Llobregat)
Hospital Duran i Reynals, Gran Via 199,
L’Hospitalet del Llobregat,
Barcelona 08908
Tel. +34 93 260 7952
Campus IGTP-IJC
(Badalona)
Campus Can Ruti – IGTP – Building Muntanya,
Rd. Can Ruti, Camí de les escoles s/n,
Badalona, Barcelona 08916
Tel. +34 93 554 3069
Campus IDIBGI
(Girona)
Parc Hospitalari Martí i Julià de Salt, Dr. Castany s/n,
Salt, Girona 17190
Tel. +34 872 987 087
Sureda’s & Farre’s Lab