Unlocking the metabolic secrets of cancer: Our “Metabolism and Cancer” team studies how cellular metabolism drives cancer growth, drug resistance, and metastasis. We use cutting-edge laboratory experiments, computational tools and clinical trials to validate our discoveries in cancer patients.
MAIN RESEARCH LINES
Metabolic inhibitors for cancer therapy
Mitochondria, senescence, and cancer
Metabolo-immunotherapy
Group members
IP
Established researcher (Miguel Servet)
Postdoctoral researcher (INVESTIGO)
Predoctoral researcher
Predoctoral researcher
Predoctoral researcher
Established researcher (Unit of Clinical Research, ICO-Girona)
Established researcher (Hospital Trueta)
Publications
Oncotarget. 2017 Oct 15;8(59):99223-99236. doi: 10.18632/oncotarget.21834. eCollection 2017 Nov 21. ABSTRACT Personalized cancer medicine based on the analysis of tumors en masse is limited by tumor heterogeneity, which has become a major obstacle to effective cancer treatment. Cancer stem cells (CSC) are emerging as key drivers of inter- and intratumoral heterogeneity. CSC have unique metabolic […]
Int J Mol Sci. 2017 Oct 28;18(11):2263. doi: 10.3390/ijms18112263. ABSTRACT Prevention of the metabolic consequences of a chronic energy-dense/high-fat diet (HFD) represents a public health priority. Metformin is a strong candidate to be incorporated in alternative therapeutic approaches. We used a targeted metabolomic approach to assess changes related to the multi-faceted metabolic disturbances provoked by […]
Oncogene. 2018 Feb 15;37(7):963-970. doi: 10.1038/onc.2017.367. Epub 2017 Oct 23. ABSTRACT The anti-diabetic biguanide metformin may exert health-promoting effects via metabolic regulation of the epigenome. Here we show that metformin promotes global DNA methylation in non-cancerous, cancer-prone and metastatic cancer cells by decreasing S-adenosylhomocysteine (SAH), a strong feedback inhibitor of S-adenosylmethionine (SAM)-dependent DNA methyltransferases, while […]
J Colloid Interface Sci. 2018 Feb 1;511:27-38. doi: 10.1016/j.jcis.2017.09.091. Epub 2017 Sep 23. ABSTRACT The adsorption of cytochrome c in water onto organic and carbon xerogels with narrow pore size distributions has been studied by carrying out transient and equilibrium batch adsorption experiments. It was found that equilibrium adsorption exhibits a quasi-Langmuirian behavior (a g […]
Expert Opin Ther Targets. 2017 Nov;21(11):1001-1016. doi: 10.1080/14728222.2017.1381087. Epub 2017 Sep 21. ABSTRACT Ten years ago, we put forward the metabolo-oncogenic nature of fatty acid synthase (FASN) in breast cancer. Since the conception of this hypothesis, which provided a model to explain how FASN is intertwined with various signaling networks to cell-autonomously regulate breast cancer […]
Collaborations
Ruth Lupu | Mayo Clinic, Rochester, USA
Pilar Blancafort | Harry Perkins Institute of Medical Research, Perth, Australia
Francesca Cutruzzolà | Sapienza University, Rome, Italy
Tomás Alarcón | ICREA-Centre de Recerca Matemàtica (CRM), Reus, Spain
Sílvia Osuna | ICREA-Institut de Química Computacional i Catàlisi (IQCC), Girona, Spain
Josep Sardanyés | Centre de Recerca Matemàtica (CRM), Barcelona, Spain
José Antonio Encinar | Universidad Miguel Hernández, Elche, Spain
Vicente Micol | Universidad Miguel Hernández, Elche, Spain
Antonio Segura-Carretero | Universidad de Granada, Granada, Spain
Jorge Joven | Institut d’Investigació Sanitària Pere Virgili (IISPV), Reus, Spain
Carlos Peña Garay | Laboratorio Subterráneo de Canfranc (LSC), Spain
Campus IDIBELL
(L’Hospitalet del Llobregat)
Hospital Duran i Reynals, Gran Via 199,
L’Hospitalet del Llobregat,
Barcelona 08908
Tel. +34 93 260 7952
Campus IGTP-IJC
(Badalona)
Campus Can Ruti – IGTP – Building Muntanya,
Rd. Can Ruti, Camí de les escoles s/n,
Badalona, Barcelona 08916
Tel. +34 93 554 3069
Campus IDIBGI
(Girona)
Parc Hospitalari Martí i Julià de Salt, Dr. Castany s/n,
Salt, Girona 17190
Tel. +34 872 987 087
Sureda’s & Farre’s Lab