Tumor angiogenesis group
Casanovas’ Lab

DESCRIPTION

Mechanisms of resistance to antiangiogenic therapies.
Therapeutic studies in Kidney Cancer murine models, both PDOX and syngenic.
Therapeutic studies in pancreatic NeuroEndocrine tumors.
Discovery of non-invasive biomarkers in clinical trials with antiangiogenics.

Our research group at the ProCURE Program (Catalan Institute of Oncology) and OncoBell Program (IDIBELL) is focused on determining the consequences of adaptation and resistance to anti-angiogenic cancer therapy. For that we use translational research in murine models of cancer, particularly Kindey Cancer PDOX models and NeuroEndocrine transgenic models to study in vivo mechanisms of adaptation to anti-angiogenics, and validate our findings using clinical samples from our hospital and collaborating institutions.
Our scientific achievements have been published in prestigious journals in the field of cancer research with numerous “preview”, “highlight” or commentary articles in high impact scientific journals. Furthermore, we have an important international position in the field of antitumor therapies and angiogenic resistance mechanisms.

Group members

Felix-Joan Peix

Young investigators

Laura Puigròs

Young investigators

Jessica Videira

Young investigators

Maria Del Mar Martinez Lozano

Support staff

Irene Ortiz-Rubio

Researchers

Laura Bernaus

Support staff

Publications

Anti-angiogenesis and metastasis: a tumour and stromal cell alliance

4 de December de 2012/in Casanovas's Lab/by miguel

J Intern Med. 2013 Feb;273(2):128-37. doi: 10.1111/joim.12018. ABSTRACT Tumour progression requires the activation of a tumour and stromal cell-driven angiogenic programme, and the targeting of this process demonstrates an impact on tumour growth and progression. The results of preclinical studies have demonstrated a proinvasive/metastatic effect of antiangiogenic treatments with recent evidence supporting a contribution of […]

Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis

5 de September de 2012/in Casanovas's Lab/by miguel

Oncogene. 2013 Aug 8;32(32):3732-43. doi: 10.1038/onc.2012.375. Epub 2012 Sep 3. ABSTRACT Epidermal keratinocytes and hair follicle (HF) stem cells (SCs) expressing oncogenes are competent at developing squamous cell carcinomas (SCCs) in epidermis and HFs, respectively. To determine whether bulge and hair germ (HG) SCs from HF contribute to SCC generation at distant epidermis, the most […]

Relevance of angiogenesis in neuroendocrine tumors

18 de May de 2012/in Casanovas's Lab/by miguel

Target Oncol. 2012 Jun;7(2):93-8. doi: 10.1007/s11523-012-0217-x. Epub 2012 May 17. ABSTRACT While traditional cytotoxic drugs have shown limited efficacy in neuroendocrine tumors (NETs), their biological features have been characterized and can be exploited therapeutically. Their most prominent trait is an extraordinary vascularization in low-grade NETs and an hypoxia-dependent angiogenesis in high-grade NETs, which is associated […]

Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice

10 de April de 2012/in Casanovas's Lab/by miguel

J Clin Invest. 2012 May;122(5):1832-48. doi: 10.1172/JCI58976. Epub 2012 Apr 9. ABSTRACT Cancer development, progression, and metastasis are highly dependent on angiogenesis. The use of antiangiogenic drugs has been proposed as a novel strategy to interfere with tumor growth, but cancer cells respond by developing strategies to escape these treatments. In particular, animal models show […]

Cancer: Limitations of therapies exposed

7 de April de 2012/in Casanovas's Lab/by miguel

Nature. 2012 Apr 4;484(7392):44-6. doi: 10.1038/484044a. NO ABSTRACT PMID:22481354 | DOI:10.1038/484044a

Research Projects

MICIU PID2022-142386OB-I00 Disección de los mecanismos de Plaquetas y genes de Coagulación en la metástasis del Cancer de Riñón Oriol Casanovas 325.000,00 €PREP2022-000672 Disección de los mecanismos de Plaquetas y genes de Coagulación en la metástasis del Cancer de Riñón Oriol Casanovas 111.758,00 €
Proyecto PID2022-142386OB-I00 financiado por MCIU/AEI/10.13039/501100011033 y por FEDER, UE
MTV3 201910-30 Identification of Kidney Cancer progression targets and biomarkers through CRISPRengineered organoids and xenograft mouse models Oriol Casanovas 136.250,00 €
MICIU PID2019-107557RB-I00 Targeteando la Coagulación en la formación de metástasis en cáncer renal Oriol Casanovas 145.200,00 €
Proyecto PID2019-107557RB-I00 financiado por MICIU/AEI /10.13039/501100011033
AGAUR 2021 SGR 01289 Interacció Tumor Estroma i Resistència Terapèutica – ITERT Oriol Casanovas 40.000,00 €

Tech Transfer Projects
MICIU CPP2023-010718 Opening a New Era in Hepatocellular Carcinoma by a Novel Blood Biomarker for Individual Selection of Treatment (PersonalHCC) Oriol Casanovas 514.874,00 €
Proyecto CPP2023-010718 financiado por MICIU/AEI/10.13039/501100011033 y por FEDER, UE.
AGAUR 2022 DI 00052 Inhibiting Cannibalism to Fight Resistant Tumors Oriol Casanovas 33.960,00 €
MICIU PDC2021-121308-I00 Desarrollo de un nuevo biomarcador y su ‘kit’ prototipo para predecir la Respuesta Agresiva en Cancer Oriol Casanovas 132.250,00 €
Proyecto PDC2021-121308-I00 financiado por MCIU/AEI/10.13039/501100011033 y por la Unión Europea NextGenerationEU/ PRTR
ISCIII DTS21/00163 Angiotheragnostics: Desarrollo de un nuevo tratamiento con su biomarcador de selección de pacientes para pacientes con cáncer colorectal avanzado. Oriol Casanovas 149.600,00 €

Collaborations

International:
Douglas Hanahan, ISREC

Gabriele Bergers, KULeuven

Masahiro Inoue, Univ.Osaka

Kristian Pietras, Karolinska I.

Enrico Giraudo, IRCC

Stefano Indraccolo, IOV

National:

Joan Carles, VHIO

Cristina Suárez, VHIO

Maria Ochoa, ICO

August Vidal, HUB

Ramon Salazar, ICO

X García del Muro, ICO

Tumor angiogenesis groupCasanovas’ Lab

DESCRIPTION

Felix-Joan Peix

Young investigators

Laura Puigròs

Young investigators

Jessica Videira

Young investigators

Maria Del Mar Martinez Lozano

Support staff

Irene Ortiz-Rubio

Researchers

Laura Bernaus

Support staff

Tech Transfer Projects

CONTACT US

Tumor angiogenesis group
Casanovas’ Lab