Our research is focused on the study of the implication of intracellular signaling cascades driving to pathological situations in cancer and vascular diseases.
The molecular signaling cascades that take place inside the cells are essential to respond to changes in their environment or to alter their homeostasis, for example, at the level of cell proliferation, movement, growth or metabolism. Understanding how these mechanisms of signal transduction work can explain how biological processes are controlled in a normal physiological context, but also, the alterations that take place in many pathologies. Our group investigates this in two pathological contexts: The first is ovarian epithelial cancer, where we study the pathways involved in metastasis and the mechanisms of resistance to therapies. A second context is a rare vascular disease, HHTs, in which, in collaboration with the group led by Toni Riera (Hospital de Bellvitge), we study which signaling pathways are altered in patients with mutations that cause this disease, and how treat them with new drugs.
Group members
Group Leader
Publications
Gene. 2003 Dec 11;322:47-55. doi: 10.1016/j.gene.2003.09.003. ABSTRACT Expression of the glucose transporter GLUT1 is high in proliferating and tumour cells. Conditions in which the transcriptional activity of GLUT1 promoter are maximal are characterized by the operation of activators such as Sp1 and inhibitors as Sp3. Here, we have identified an element at -67/-60 (C8 box) […]
Ultrasound Obstet Gynecol. 2003 Oct;22(4):388-94. doi: 10.1002/uog.883. ABSTRACT OBJECTIVE: To assess the feasibility and capability of STIC acquisition, performed by a general obstetrician performing antenatal ultrasound, to visualize fetal cardiac structures in women undergoing routine obstetric ultrasound examination, in order to obtain information to confirm normality of the fetal heart during intrauterine life. METHODS: This […]
Ultrasound Obstet Gynecol. 2003 Oct;22(4):358-67. doi: 10.1002/uog.882. ABSTRACT OBJECTIVE: To analyse the anomalies seen at the three vessels and trachea (3VT) view in fetuses with antenatally diagnosed congenital heart disease (CHD), specifically in defects involving the upper mediastinum, including the outflow tracts and/or arteries. METHODS: Seventy-four consecutive fetuses of singleton pregnancies with antenatally diagnosed structural […]
FEBS Lett. 2003 Aug 28;550(1-3):23-9. doi: 10.1016/s0014-5793(03)00808-1. ABSTRACT 6-Phosphofructo-2-kinase catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, activator of phosphofructokinase-1 and inhibitor of fructose 1,6-bisphosphatase. These properties confer to this bifunctional enzyme a key role in the control of glycolysis and gluconeogenesis. Several mammalian isozymes generated by alternative splicing from four genes, designated pfkfb1-4, have […]
Mol Endocrinol. 2003 Jul;17(7):1332-43. doi: 10.1210/me.2002-0254. Epub 2003 Apr 3. ABSTRACT Chondrogenesis leads to the formation of mature cartilage and generates initial skeletal elements that serve as templates for endochondral bone formation. Bone morphogenetic proteins (BMPs) are involved in several developmental and organogenetic processes and have been identified as key regulators in chondrogenesis. In the […]
Research Projects
– Ref: PID2020-117815RB-I00 Title: El perfil metabólico como una oportunidad terapéutica en el cáncer epitelial de ovario. implicaciones en metástasis y resistencia a los tratamientos. DGICYT, MINECO. 2021-2024. 217.800 euros. Principal Investigator: Francesc Viñals Canals, IDIBELL.
– Ref: SAF2017-85869-R Title: Mecanismos de señalización y control metabólico implicados en la diseminación y quimioresistencia en cáncer epitelial de ovario. DGICYT, MINECO. 2018-2020. 181.500 euros. Principal Investigator: Francesc Viñals Canals, IDIBELL.
Collaborations
Peter B. Vermeulen, University of Antwerp and GZA Hospitals, Belgium
Artur Mezheyeuski, VHIO, Barcelona
Pnina Brodt, Mc Gill University, Montreal, Canada
and Liver Metastases Research Network members
Campus IDIBELL
(L’Hospitalet del Llobregat)
Hospital Duran i Reynals, Gran Via 199,
L’Hospitalet del Llobregat,
Barcelona 08908
Tel. +34 93 260 7952
Campus IGTP-IJC
(Badalona)
Campus Can Ruti – IGTP – Building Muntanya,
Rd. Can Ruti, Camí de les escoles s/n,
Badalona, Barcelona 08916
Tel. +34 93 554 3069
Campus IDIBGI
(Girona)
Parc Hospitalari Martí i Julià de Salt, Dr. Castany s/n,
Salt, Girona 17190
Tel. +34 872 987 087
