Unlocking the metabolic secrets of cancer: Our “Metabolism and Cancer” team studies how cellular metabolism drives cancer growth, drug resistance, and metastasis. We use cutting-edge laboratory experiments, computational tools and clinical trials to validate our discoveries in cancer patients.
MAIN RESEARCH LINES
Metabolic inhibitors for cancer therapy
Mitochondria, senescence, and cancer
Metabolo-immunotherapy
Group members
IP
Established researcher (Miguel Servet)
Postdoctoral researcher (INVESTIGO)
Predoctoral researcher
Predoctoral researcher
Predoctoral researcher
Established researcher (Unit of Clinical Research, ICO-Girona)
Established researcher (Hospital Trueta)
Publications
Biomolecules. 2020 May 18;10(5):780. doi: 10.3390/biom10050780. ABSTRACT The biguanide metformin is the first drug to be tested as a gerotherapeutic in the clinical trial TAME (Targeting Aging with Metformin). The current consensus is that metformin exerts indirect pleiotropy on core metabolic hallmarks of aging, such as the insulin/insulin-like growth factor 1 and AMP-activated protein kinase/mammalian […]
Viruses. 2020 May 10;12(5):525. doi: 10.3390/v12050525. ABSTRACT The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causing the COVID-19 respiratory disease pandemic utilizes unique 2′-O-methyltransferase (2′-O-MTase) capping machinery to camouflage its RNA from innate immune recognition. The nsp16 catalytic subunit of the 2′-O-MTase is unusual in its requirement for a stimulatory subunit (nsp10) to catalyze the ribose […]
Aging (Albany NY). 2020 Mar 18;12(6):4794-4814. doi: 10.18632/aging.102887. Epub 2020 Mar 18. ABSTRACT SOX2 is a core pluripotency-associated transcription factor causally related to cancer initiation, aggressiveness, and drug resistance by driving the self-renewal and seeding capacity of cancer stem cells (CSC). Here, we tested the ability of the clinically proven inhibitor of the lysine-specific demethylase […]
Front Chem. 2020 Jan 24;8:3. doi: 10.3389/fchem.2020.00003. eCollection 2020. ABSTRACT This study focuses on the use of a microwave reactor that combines biomass pyrolysis, at mild temperature, with catalytic reforming of the pyrolytic gas, using activated carbon, for generating hydrogen-rich synthesis gas. The traditional pyrolysis of biomass coupled with the reforming of its pyrolytic yields […]
Aging (Albany NY). 2020 Jan 4;12(1):8-34. doi: 10.18632/aging.102646. Epub 2020 Jan 4. ABSTRACT New strategies to block the immune evasion activity of programmed death ligand-1 (PD-L1) are urgently needed. When exploring the PD-L1-targeted effects of mechanistically diverse metabolism-targeting drugs, exposure to the dietary polyphenol resveratrol (RSV) revealed its differential capacity to generate a distinct PD-L1 […]
Collaborations
Ruth Lupu | Mayo Clinic, Rochester, USA
Pilar Blancafort | Harry Perkins Institute of Medical Research, Perth, Australia
Francesca Cutruzzolà | Sapienza University, Rome, Italy
Tomás Alarcón | ICREA-Centre de Recerca Matemàtica (CRM), Reus, Spain
Sílvia Osuna | ICREA-Institut de Química Computacional i Catàlisi (IQCC), Girona, Spain
Josep Sardanyés | Centre de Recerca Matemàtica (CRM), Barcelona, Spain
José Antonio Encinar | Universidad Miguel Hernández, Elche, Spain
Vicente Micol | Universidad Miguel Hernández, Elche, Spain
Antonio Segura-Carretero | Universidad de Granada, Granada, Spain
Jorge Joven | Institut d’Investigació Sanitària Pere Virgili (IISPV), Reus, Spain
Carlos Peña Garay | Laboratorio Subterráneo de Canfranc (LSC), Spain
Campus IDIBELL
(L’Hospitalet del Llobregat)
Hospital Duran i Reynals, Gran Via 199,
L’Hospitalet del Llobregat,
Barcelona 08908
Tel. +34 93 260 7952
Campus IGTP-IJC
(Badalona)
Campus Can Ruti – IGTP – Building Muntanya,
Rd. Can Ruti, Camí de les escoles s/n,
Badalona, Barcelona 08916
Tel. +34 93 554 3069
Campus IDIBGI
(Girona)
Parc Hospitalari Martí i Julià de Salt, Dr. Castany s/n,
Salt, Girona 17190
Tel. +34 872 987 087
Sureda’s & Farre’s Lab