A machine learning and live-cell imaging tool kit uncovers small molecules induced phospholipidosis
Cell Chem Biol. 2023 Sep 27:S2451-9456(23)00322-7. doi: 10.1016/j.chembiol.2023.09.003.…
Target 2035 – an update on private sector contributions
RSC Med Chem. 2023 Mar 16;14(6):1002-1011. doi: 10.1039/d2md00441k.…
canSAR: update to the cancer translational research and drug discovery knowledgebase
Nucleic Acids Res. 2023 Jan 6;51(D1):D1212-D1219. doi: 10.1093/nar/gkac1004.ABSTRACTcanSAR…
The Chemical Probes Portal: an expert review-based public resource to empower chemical probe assessment, selection and use
Nucleic Acids Res. 2023 Jan 6;51(D1):D1492-D1502. doi: 10.1093/nar/gkac909.ABSTRACTWe…
canSAR chemistry registration and standardization pipeline
J Cheminform. 2022 May 28;14(1):28. doi: 10.1186/s13321-022-00606-7.ABSTRACTBACKGROUND:…
Rare Variation in Drug Metabolism and Long QT Genes and the Genetic Susceptibility to Acquired Long QT Syndrome
Circ Genom Precis Med. 2022 Feb;15(1):e003391. doi: 10.1161/CIRCGEN.121.003391.…
AI delivers Michaelis constants as fuel for genome-scale metabolic models
PLoS Biol. 2021 Oct 20;19(10):e3001415. doi: 10.1371/journal.pbio.3001415.…
Identification of different side effects between PARP inhibitors and their polypharmacological multi-target rationale
Br J Clin Pharmacol. 2022 Feb;88(2):742-752. doi: 10.1111/bcp.15015.…
Evolution of kinase polypharmacology across HSP90 drug discovery
Cell Chem Biol. 2021 Oct 21;28(10):1433-1445.e3. doi: 10.1016/j.chembiol.2021.05.004.…
canSAR: update to the cancer translational research and drug discovery knowledgebase
Nucleic Acids Res. 2021 Jan 8;49(D1):D1074-D1082. doi: 10.1093/nar/gkaa1059.ABSTRACTcanSAR…
The kinase polypharmacology landscape of clinical PARP inhibitors
Sci Rep. 2020 Feb 17;10(1):2585. doi: 10.1038/s41598-020-59074-4.ABSTRACTPolypharmacology…
Public resources for chemical probes: the journey so far and the road ahead
Future Med Chem. 2021 Apr;13(8):731-747. doi: 10.4155/fmc-2019-0231.…
