Unlocking the metabolic secrets of cancer: Our “Metabolism and Cancer” team studies how cellular metabolism drives cancer growth, drug resistance, and metastasis. We use cutting-edge laboratory experiments, computational tools and clinical trials to validate our discoveries in cancer patients.
MAIN RESEARCH LINES
Metabolic inhibitors for cancer therapy
Mitochondria, senescence, and cancer
Metabolo-immunotherapy
Group members
IP
Established researcher (Miguel Servet)
Postdoctoral researcher (INVESTIGO)
Predoctoral researcher
Predoctoral researcher
Predoctoral researcher
Established researcher (Unit of Clinical Research, ICO-Girona)
Established researcher (Hospital Trueta)
Publications
Lung Cancer. 2024 Oct 20;197:107995. doi: 10.1016/j.lungcan.2024.107995. Online ahead of print. ABSTRACT BACKGROUND: Lung cancer (LC) is Europe’s primary cause of cancer-related mortality largely due to its historically low survival rates. The aim of this study was to analyze 26-year survival trends in the province of Girona, Spain, and to identify key prognostic factors. METHODS: […]
Cell Death Discov. 2024 Sep 30;10(1):417. doi: 10.1038/s41420-024-02184-z. ABSTRACT Fatty acid synthase (FASN)-catalyzed endogenous lipogenesis is a hallmark of cancer metabolism. However, whether FASN is an intrinsic mechanism of tumor cell defense against T cell immunity remains unexplored. To test this hypothesis, here we combined bioinformatic analysis of the FASN-related immune cell landscape, real-time assessment […]
bioRxiv [Preprint]. 2024 Apr 22:2024.04.18.589952. doi: 10.1101/2024.04.18.589952. ABSTRACT A remarkable demonstration of the flexibility of mammalian motor systems is primates’ ability to learn to control brain-computer interfaces (BCIs). This constitutes a completely novel motor behavior, yet primates are capable of learning to control BCIs under a wide range of conditions. BCIs with carefully calibrated decoders, […]
Phytomedicine. 2024 Mar 6;128:155493. doi: 10.1016/j.phymed.2024.155493. Online ahead of print. ABSTRACT BACKGROUND: ID3 (inhibitor of DNA binding/differentiation-3) is a transcription factor that enables metastasis by promoting stem cell-like properties in endothelial and tumor cells. The milk thistle flavonolignan silibinin is a phytochemical with anti-metastatic potential through largely unknown mechanisms. HYPOTHESIS/PURPOSE: We have mechanistically investigated the […]
Mol Oncol. 2023 Dec 29. doi: 10.1002/1878-0261.13582. Online ahead of print. ABSTRACT The initial excitement generated more than two decades ago by the discovery of drugs targeting fatty acid synthase (FASN)-catalyzed de novo lipogenesis for cancer therapy was short-lived. However, the advent of the first clinical-grade FASN inhibitor (TVB-2640; denifanstat), which is currently being studied […]
Collaborations
Ruth Lupu | Mayo Clinic, Rochester, USA
Pilar Blancafort | Harry Perkins Institute of Medical Research, Perth, Australia
Francesca Cutruzzolà | Sapienza University, Rome, Italy
Tomás Alarcón | ICREA-Centre de Recerca Matemàtica (CRM), Reus, Spain
Sílvia Osuna | ICREA-Institut de Química Computacional i Catàlisi (IQCC), Girona, Spain
Josep Sardanyés | Centre de Recerca Matemàtica (CRM), Barcelona, Spain
José Antonio Encinar | Universidad Miguel Hernández, Elche, Spain
Vicente Micol | Universidad Miguel Hernández, Elche, Spain
Antonio Segura-Carretero | Universidad de Granada, Granada, Spain
Jorge Joven | Institut d’Investigació Sanitària Pere Virgili (IISPV), Reus, Spain
Carlos Peña Garay | Laboratorio Subterráneo de Canfranc (LSC), Spain
Campus IDIBELL
(L’Hospitalet del Llobregat)
Hospital Duran i Reynals, Gran Via 199,
L’Hospitalet del Llobregat,
Barcelona 08908
Tel. +34 93 260 7952
Campus IGTP-IJC
(Badalona)
Campus Can Ruti – IGTP – Building Muntanya,
Rd. Can Ruti, Camí de les escoles s/n,
Badalona, Barcelona 08916
Tel. +34 93 554 3069
Campus IDIBGI
(Girona)
Parc Hospitalari Martí i Julià de Salt, Dr. Castany s/n,
Salt, Girona 17190
Tel. +34 872 987 087
Sureda’s & Farre’s Lab