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Tumor angiogenesis group
Casanovas’ Lab

DESCRIPTION

Mechanisms of resistance to antiangiogenic therapies.
Therapeutic studies in Kidney Cancer murine models, both PDOX and syngenic.
Therapeutic studies in pancreatic NeuroEndocrine tumors.
Discovery of non-invasive biomarkers in clinical trials with antiangiogenics.

Our research group at the ProCURE Program (Catalan Institute of Oncology) and OncoBell Program (IDIBELL) is focused on determining the consequences of adaptation and resistance to anti-angiogenic cancer therapy. For that we use translational research in murine models of cancer, particularly Kindey Cancer PDOX models and NeuroEndocrine transgenic models to study in vivo mechanisms of adaptation to anti-angiogenics, and validate our findings using clinical samples from our hospital and collaborating institutions.
Our scientific achievements have been published in prestigious journals in the field of cancer research with numerous “preview”, “highlight” or commentary articles in high impact scientific journals. Furthermore, we have an important international position in the field of antitumor therapies and angiogenic resistance mechanisms.

Felix-Joan Peix

Young investigators

Laura Puigròs

Young investigators

Jessica Videira

Young investigators

Maria Del Mar Martinez Lozano

Support staff

Irene Ortiz-Rubio

Researchers

Laura Bernaus

Support staff

Incomplete inhibition of the Rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesis

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Oncogene. 2005 Oct 6;24(44):6597-604. doi: 10.1038/sj.onc.1208823. ABSTRACT Here, we describe the surprising residual capability of the Rb pathway to negatively regulate proliferation and tumorigenesis in a SV40 large T antigen (Tag)-driven mouse model of pancreatic islet carcinogenesis. Heterogeneous Tag expression during all progression stages suggested that a threshold level of the T antigen oncoprotein might […]

P38SAPK2 phosphorylates cyclin D3 at Thr-283 and targets it for proteasomal degradation

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Oncogene. 2004 Sep 30;23(45):7537-44. doi: 10.1038/sj.onc.1208040. ABSTRACT Cyclin D3 plays a critical role in maturation of precursor T cells and their levels are tightly regulated during this process. Alteration of cyclin D3 levels has been proposed to be important in the development of different human cancers, including malignancies of the lymphoid system. Thus, we have […]

The p21(Cip1) protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers

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Hepatology. 2002 May;35(5):1063-71. doi: 10.1053/jhep.2002.32678. ABSTRACT Liver cells from p21(Cip1-/-) mice subjected to partial hepatectomy (PH) progress into DNA synthesis faster than those from wild-type mice. These cells also show a premature induction of cyclin E/cyclin-dependent kinase (CDK) 2 activity. We studied the mechanisms whereby cells lacking p21(Cip1) showed a premature induction of this activity. […]

Osmotic stress regulates the stability of cyclin D1 in a p38SAPK2-dependent manner

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J Biol Chem. 2000 Nov 10;275(45):35091-7. doi: 10.1074/jbc.M006324200. ABSTRACT We report here that different cell stresses regulate the stability of cyclin D1 protein. Exposition of Granta 519 cells to osmotic shock, oxidative stress, and arsenite induced the post-transcriptional down-regulation of cyclin D1. In the case of osmotic shock, this effect was completely reversed by the […]

The protein SET regulates the inhibitory effect of p21(Cip1) on cyclin E-cyclin-dependent kinase 2 activity

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J Biol Chem. 1999 Nov 12;274(46):33161-5. doi: 10.1074/jbc.274.46.33161. ABSTRACT The cyclin-dependent kinase (CDK) inhibitor p21(Cip1) has a dual role in the regulation of the cell cycle; it is an activator of cyclin D1-CDK4 complexes and an inhibitor of cyclins E/A-CDK2 activity. By affinity chromatography with p21(Cip1)-Sepharose 4B columns, we purified a 39-kDa protein, which was […]

  1. MICIU PID2022-142386OB-I00 Disección de los mecanismos de Plaquetas y genes de Coagulación en la metástasis del Cancer de Riñón Oriol Casanovas 325.000,00 €PREP2022-000672 Disección de los mecanismos de Plaquetas y genes de Coagulación en la metástasis del Cancer de Riñón Oriol Casanovas 111.758,00 €
    Proyecto PID2022-142386OB-I00 financiado por MCIU/AEI/10.13039/501100011033 y por FEDER, UE
  2. MTV3 201910-30 Identification of Kidney Cancer progression targets and biomarkers through CRISPRengineered organoids and xenograft mouse models Oriol Casanovas 136.250,00 €
  3. MICIU PID2019-107557RB-I00 Targeteando la Coagulación en la formación de metástasis en cáncer renal Oriol Casanovas 145.200,00 €
    Proyecto PID2019-107557RB-I00 financiado por MICIU/AEI /10.13039/501100011033
  4. AGAUR 2021 SGR 01289 Interacció Tumor Estroma i Resistència Terapèutica – ITERT Oriol Casanovas 40.000,00 €

    Tech Transfer Projects

  5. MICIU CPP2023-010718 Opening a New Era in Hepatocellular Carcinoma by a Novel Blood Biomarker for Individual Selection of Treatment (PersonalHCC) Oriol Casanovas 514.874,00 €
    Proyecto CPP2023-010718 financiado por MICIU/AEI/10.13039/501100011033 y por FEDER, UE.
  6. AGAUR 2022 DI 00052 Inhibiting Cannibalism to Fight Resistant Tumors Oriol Casanovas 33.960,00 €
  7. MICIU PDC2021-121308-I00 Desarrollo de un nuevo biomarcador y su ‘kit’ prototipo para predecir la Respuesta Agresiva en Cancer Oriol Casanovas 132.250,00 €
    Proyecto PDC2021-121308-I00 financiado por MCIU/AEI/10.13039/501100011033 y por la Unión Europea NextGenerationEU/ PRTR
  8. ISCIII DTS21/00163 Angiotheragnostics: Desarrollo de un nuevo tratamiento con su biomarcador de selección de pacientes para pacientes con cáncer colorectal avanzado. Oriol Casanovas 149.600,00 €


International:
Douglas Hanahan, ISREC

Gabriele Bergers, KULeuven

Masahiro Inoue, Univ.Osaka

Kristian Pietras, Karolinska I.

Enrico Giraudo, IRCC

Stefano Indraccolo, IOV


National:

Joan Carles, VHIO

Cristina Suárez, VHIO

Maria Ochoa, ICO

August Vidal, HUB

Ramon Salazar, ICO

X García del Muro, ICO

Program Against Cancer Therapeutic Resistance

CONTACT US

Campus IDIBELL
(L’Hospitalet del Llobregat)
Hospital Duran i Reynals, Gran Via 199,
L’Hospitalet del Llobregat,
Barcelona 08908
Tel. +34 93 260 7952

Campus IGTP-IJC
(Badalona)
Campus Can Ruti – IGTP – Building Muntanya,
Rd. Can Ruti, Camí de les escoles s/n,
Badalona, Barcelona 08916
Tel. +34 93 554 3069

Campus IDIBGI
(Girona)
Parc Hospitalari Martí i Julià de Salt, Dr. Castany s/n,
Salt, Girona 17190
Tel. +34 872 987 087

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