DNA double-strand break-capturing nuclear envelope tubules drive DNA repair
Nat Struct Mol Biol. 2024 Apr 17. doi: 10.1038/s41594-024-01286-7.…
Large-scale genome-wide association study of 398,238 women unveils seven novel loci associated with high-grade serous epithelial ovarian cancer risk
medRxiv [Preprint]. 2024 Mar 4:2024.02.29.24303243. doi: 10.1101/2024.02.29.24303243.ABSTRACTBACKGROUND:…
Identification of differential biological activity and synergy between the PARP inhibitor rucaparib and its major metabolite
Cell Chem Biol. 2024 Feb 6:S2451-9456(24)00043-6. doi: 10.1016/j.chembiol.2024.01.007.…
Biological basis of extensive pleiotropy between blood traits and cancer risk
Genome Med. 2024 Feb 2;16(1):21. doi: 10.1186/s13073-024-01294-8.ABSTRACTBACKGROUND:…
Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality
Cancer Res. 2023 Nov 21:OF1-OF15. doi: 10.1158/0008-5472.CAN-22-2948.…
Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages
Cell Rep. 2023 Oct 25;42(11):113382. doi: 10.1016/j.celrep.2023.113382.…
Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages
Cell Rep. 2023 Oct 31;42(10):113256. doi: 10.1016/j.celrep.2023.113256.…
RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells
Nucleic Acids Res. 2023 Oct 27;51(19):10484-10505. doi: 10.1093/nar/gkad733.ABSTRACTBreast…
PREDICT validity for prognosis of breast cancer patients with pathogenic BRCA1/2 variants
NPJ Breast Cancer. 2023 May 12;9(1):37. doi: 10.1038/s41523-023-00546-x.ABSTRACTWe…
Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers
Nucleic Acids Res. 2023 May 22;51(9):4341-4362. doi: 10.1093/nar/gkad172.ABSTRACTBRCA1…
Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer
Cancer Discov. 2022 Dec 2;12(12):2930-2953. doi: 10.1158/2159-8290.CD-21-0865.ABSTRACTSystematically…
A High-Throughput Screening Platform Identifies Novel Combination Treatments for Malignant Peripheral Nerve Sheath Tumors
Mol Cancer Ther. 2022 Jul 5;21(7):1246-1258. doi: 10.1158/1535-7163.MCT-21-0947.ABSTRACTMalignant…
