Recent Advances in Understanding the Biology of Castration-Resistant Prostate Cancer

Urol Clin North Am. 2026 May;53(2):303-315. doi: 10.1016/j.ucl.2026.02.012. Epub 2026 Mar 12.

ABSTRACT

Prostate cancer progression is largely driven by androgen receptor signaling. While androgen deprivation therapy remains a cornerstone of treatment, it imposes a selective pressure that ultimately leads to the emergence of a castration-resistant phenotype, driven by a range of adaptive molecular mechanisms. In recent years, significant advances have been made in understanding its complex biology, making it a critical focus of ongoing research. The application of multi-omics approaches has played a pivotal role in uncovering the molecular underpinnings of this disease, offering deeper insights into its heterogeneity and resistance mechanisms.

PMID:41986025 | DOI:10.1016/j.ucl.2026.02.012