The Genetics and Mechanisms of T-Cell Acute Lymphoblastic Leukemia

Cold Spring Harb Perspect Med. 2020 Mar 2;10(3):a035246. doi: 10.1101/cshperspect.a035246.

ABSTRACT

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy derived from early T-cell progenitors. The recognition of clinical, genetic, transcriptional, and biological heterogeneity in this disease has already translated into new prognostic biomarkers, improved leukemia animal models, and emerging targeted therapies. This work reviews our current understanding of the molecular mechanisms of T-ALL.

PMID:31570389 | PMC:PMC7050584 | DOI:10.1101/cshperspect.a035246